Clinical outcomes with pemetrexed-based systemic therapies in RET-rearranged lung cancers

Targeting RET-rearranged lung cancers with multikinase inhibitors

A Phase 2 Single Arm Trial of Cabozantinib in Patients with Advanced RET-Rearranged Lung Cancers

BACKGROUND RET rearrangements are found in 1-2% of non-small-cell lung cancers. Cabozantinib is a multikinase inhibitor with activity against RET that produced a 10% overall response in unselected patients with lung cancers. To assess the activity of cabozantinib in patients with RET-rearranged lung cancers, we did a prospective phase 2 trial in this molecular subgroup. METHODS We enrolled pa...

Clinical outcomes in intracranial and extracranial lesions with fist-line systemic therapies in patients with brain metastases from lung cancer

Background: Lung cancer is the most common type of cancer to develop the Brain Metastases (BM), along with poor prognosis. This study evaluated the responses of different courses of fist-line systemic therapies including single chemotherapy and targeted agents or their combination for intracranial and extracranial lesions in patients with BM from lung cancer. Patients and methods: Twenty patien...

Pregnancy Outcomes in Patients with Systemic Lupus Erythematosus

Background & aim: Pregnant women with systemic lupus erythematosus (SLE) are considered to be at high risk regarding fetal complications and adverse outcomes. The aim of this study was to evaluate the fetal outcomes in pregnant women with the SLE. Methods: This retrospective study was conducted on a total of 125 patients with the SLE referred to the Clinic and Department of Rheumatology of Imam...

Antitumor Activity and Acquired Resistance Mechanism of Dovitinib (TKI258) in RET-Rearranged Lung Adenocarcinoma.

RET rearrangement is a newly identified oncogenic mutation in lung adenocarcinoma (LADC). Activity of dovitinib (TKI258), a potent inhibitor of FGFR, VEGFR, and PDGFR, in RET-rearranged LADC has not been reported. The aims of the study are to explore antitumor effects and mechanisms of acquired resistance of dovitinib in RET-rearranged LADC. Using structural modeling and in vitro analysis, we d...